My Infoline Forum
 flag  India flag
sub icon

Study reveals new strategy for treating pancreatic cancer

London, Dec 25 : Scientists have found a new strategy to selectively kill pancreatic cancer cells without harming normal cells, a study says.

Scientists from The University of Manchester and part of the Manchester Cancer Research Centre believe they have discovered a new way to make chemotherapy treatment more effective for pancreatic cancer patients.
ADVERTISEMENT

Pancreatic cancer is an aggressive cancer with poor prognosis and limited treatment options and is highly resistant to chemotherapy and radiotherapy.

But researchers believe they have found an effective strategy for selectively killing pancreatic cancer while sparing healthy cells which could make treatment more effective.

Jason Bruce, from the Physiological Systems and Disease Research Group, who led the research, said: "Pancreatic cancer is one of the most aggressive and deadly cancers.  Most patients develop symptoms after the tumour has spread to other organs.

To make things worse, pancreatic cancer is highly resistant to chemotherapy and radiotherapy.  Clearly a radical new approach to treatment is urgently required.  We wanted to understand how the switch in energy supply in cancer cells might help them survive."

The research, published in The Journal of Biological Chemistry this month, found pancreatic cancer cells may have their own specialised energy supply that maintains calcium levels and keeps cancer cells alive.

Maintaining a low concentration of calcium within cells is vital to their survival and this is achieved by calcium pumps on the plasma membrane, reports Science Daily.

This calcium pump, known as PMCA, is fuelled using ATP -- the key energy currency for many cellular processes.

"Designing drugs to cut off this supply to the calcium pumps might be an effective strategy for selectively killing cancer cells while sparing normal cells within the pancreas." (IANS)

 

Source: Top News



No Replies
Leave a Reply Here
Enter Your Name
Enter your Email
Enter your Contact No
Enter Your Message
Enter the code
 
   
@Copyright 2013 My Infoline -Whole World At Your Fingertips
(This site in under beta version, please feel free to send your suggestion to improve this portal , and also write a email to us if you find any bugs.)